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Usi la cannabis contro l’ansia? Un nuovo studio si propone di capire quali ceppi di cannabis sono più adatti a questo compito.

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L’ansia è una delle condizioni più comuni che le persone trattano con la cannabis, ma il modo in cui la cannabis influenza l’ansia è sempre stato complicato. La ricerca suggerisce che la cannabis sia efficace per alleviare l’ansia , ma paradossalmente, la cannabis può anche peggiorare l’ansia . 

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Ciò può essere in parte dovuto al fatto che i principi attivi principali e secondari della cannabis – THC e CBD – aiutano contro l’ansia a basse dosi, ma possono peggiorarla con dosi più elevate .

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“Questo studio ha dimostrato che le scelte dei ceppi dei pazienti non erano casuali …”ha affermato Daniel Lantela, co-fondatore e direttore dello sviluppo dei farmaci della Whistler Therapeutics.

Per aggiungere confusione, le varietà di cannabis sono diverse sia nella composizione chimica che nei loro effetti, quindi alcune possono aumentare l’ansia mentre altre la riducono.

Sfortunatamente la maggior parte delle ricerche attuali ha studiato la cannabis senza menzionare la composizione chimica dei ceppi usati, o semplicemente hanno esaminato gli effetti di un cannabinoide isolato come il THC o il CBD.

Ma i ricercatori della Whistler Therapeutics di BC, in Canada, hanno lo scopo di cambiare questa concezione, cercando l’impronta chimica della cannabis che sia adatta per alleviare l’ansia. 

Sebbene il loro studio, pubblicato in ottobre, fosse di piccole dimensioni e avesse notevoli limiti, può indicare la strada per la futura ricerca per affrontare la complicata questione di quali ceppi funzionano meglio e per quali condizioni.

Alla ricerca dei ceppi anti-ansia

Sperando di trovare una miscela di cannabinoidi e terpeni (chiamati “chemiotipi”) in grado di trattare efficacemente l’ansia, i ricercatori di questo studio hanno prima esaminato se particolari ceppi fossero associati ad una riduzione dell’ansia.

“I pazienti riferiscono di avere preferenze distinte per alcuni ceppi rispetto ad altri e poche ricerche sono state condotte per scoprire se qualcosa è diverso tra ceppi che sono utili o meno per una condizione specifica”, ha spiegato Daniel Lantela, co-fondatore e direttore dello sviluppo di farmaci presso Whistler Therapeutics.

“Chiedendo ai pazienti quali ceppi piacessero o non piacessero, potremmo correlare le loro scelte al chemiotipo”.

Per raccogliere queste informazioni i ricercatori hanno lavorato esclusivamente attraverso un dispensario, esaminando 442 dei loro pazienti analizzando i ceppi specifici ivi venduti e rivedendo due serie di test di laboratorio indipendenti sulla composizione chimica dei ceppi.

Agli intervistati è stato chiesto di valutare i ceppi più efficaci e quelli meno efficaci (da un elenco delle 25 opzioni più comunemente vendute dal dispensario) e di utilizzare una scala da uno a dieci per valutare l’efficacia di quei ceppi nel ridurre la loro ansia.

I quattro ceppi più apprezzati da Whistler Therapeutics per alleviare l’ansia erano:

  1. Bubba Kush
  2. Skywalker OG Kush
  3. Blueberry Lambsbread
  4. and Kosher Kush

I quattro ceppi meno indicati da Whistler Therapeutics per alleviare l’ansia erano:

  1. Chocolope
  2. Blueberry Lambsbread
  3. CBD Shark
  4. Tangerine Dream

Impronte chimiche

Successivamente i ricercatori si sono rivolti all’analisi dei risultati di laboratorio per i modelli chimici tra i ceppi più e meno efficaci.

L’analisi ha rivelato un pattern di alto THC e il terpene trans-nerolidol nei ceppi più efficaci. 

Tre delle quattro erano varietà Kush che condividono tutti un simile chemiotipo con alti livelli di trans-nerolidolo, b-Caryophyllene e D-limonene e contengono genetica proveniente dai ceppi landrace trovati nella catena montuosa Hindu Kush in Asia centrale.

Il trans-nerolidolo si trova in molte piante aromatiche come il gelsomino, l’albero del tè e la citronella. Fornisce un aroma floreale sommesso e sfumato con note fruttate di agrumi, mele e rose, e si ritiene che produca effetti sedativi.

I rispondenti hanno valutato la Chocolope come il ceppo meno efficace. Il terpene  terpinolene  domina la Chocolope, quindi i ricercatori sospettano che il terpinolene possa spiegare la mancanza di alcuni ceppi nell’alleviare l’ansia. Altre sative come la Jack Herer possono essere ricche di terpinolene.

Il terpene Guaiol è risultato essere l’unica correlazione “perfetta” trovata in tre dei quattro ceppi meno efficaci, ed in nessuno dei più efficaci. 

Tuttavia è stato trovato in quantità così ridotte che gli autori affermano che potrebbe essere solo un indicatore associato a chemiotipi inefficaci o che potrebbe avere effetti ansiogeni significativi. 

Altri terpeni come l’eucaliptolo, g-terpinene, a-fellandrene, 3-carene e sabinene idrato erano significativamente correlati con un ridotto effetto anti-ansia, ma erano anche presenti in quantità così piccole che non è chiaro come possano influenzare l’ansia.Alla ricerca di cannabis legale? Leafly ha tutti i tuoi menu locali

Limiti e conclusioni dello studio

Auto-segnalazione e effetto placebo

Mentre questo studio ha prodotto alcuni risultati interessanti, gli autori avvertono che i dati dovrebbero essere presi “con le pinze”. 

I sondaggi sui trattamenti medici sono notoriamente inaffidabili perché non controllano l’effetto placebo o fattori simili. Ad esempio, i pazienti possono pensare che un ceppo sia più efficace per alleviare l’ansia se hanno sentito altri provare questa sensazione, il che potrebbe influire sui risultati del sondaggio finale.

“Alla fine i ricercatori dovrebbero iniziare a guardare più in profondità i profili terpenici negli studi controllati”, spiega Lantela. “Avere degli studi ciechi sui prodotti di cannabis con vari cannabinoidi e livelli di terpeni è necessario.”

Tuttavia i sondaggi self-report sono un buon punto di partenza, perché è molto difficile testare migliaia di singoli ceppi in studi in doppio cieco controllati con placebo.

“La vasta gamma di chemiotipi rende difficile restringerne alcuni per uno studio controllato”, ha detto.

La sua speranza è che questo modello di ricerca basata sull’indagine possa aiutare a trovare buoni candidati per studi controllati.

 I ceppi di tipo Kush contenenti alto trans-nerolidolo potrebbero essere un buon punto di partenza. 

Tuttavia questo sondaggio ha utilizzato un piccolo gruppo di partecipanti e coperto un numero limitato di ceppi, pertanto è possibile che un’indagine più ampia sveli altri ceppi più o meno efficaci con profili chimici diversi.

Mancanza di generalizzabilità

Non c’è nemmeno modo di confermare che il ceppo Bubba Kush venduto a Whistler abbia lo stesso chemiotipo di Bubba Kush venduto in tutto il mondo. 

Le contraffazioni abbondano nella cannabis. Mercati diversi hanno livelli diversi di accuratezza del nome e nella “formazione” – ad esempio Los Angeles è famosa per le sue varietà contraffatte.

I Terpeni hanno sempre importanza

Mentre sono necessarie ulteriori ricerche per trovare un chemiotipo anti-ansia, Lantela sostiene che lo studio aveva ancora alcuni importanti suggerimenti da dare.

“Questo studio ha dimostrato che le scelte dei  pazienti  non erano casuali e le scelte erano correlate al contenuto specifico di ciascun terpene”, afferma aggiungendo che lo studio suggerisce anche che i pazienti rispondono in modo diverso a ceppi diversi a seconda della loro biochimica.

Il suo consiglio ai pazienti che cercano un ceppo anti-ansia?

“Ognuno è diverso, quindi continua a provare diversi ceppi finché non trovi quello che funziona meglio per te.”

FONTE: LEAFLY

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414 pensiero su “Le varietà di cannabis consigliate per chi soffre di Ansia (e quelle da evitare)”
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